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Dr. Resia Pretorious from Stellenbosch University in South Africa is leading the charge on microclotting as a Long Covid diagnostic.
- These micro-clots are abnormally large and numerous compared to other micro clotting-prevalent conditions (eg. Type 2 diabetes).
- Further, they contain elevated levels of Alpha2-Antiplasmin and other inflammatory markers, which make them resistant to tryptin. Two tryptin cycles are thus needed for analysis.
- D-dimer, gamma chain, beta chain, von willebrand, and other pathological parts are trapped in the insoluble micro clots → the soluble protein content in patients is the same as controls → normal pathology tests come back normal, and do not show up on any existing microclotting diagnostic.
- This diagnostic has been confirmed by Dr. Anna Brooks in New Zealand, who is working on developing a set of diagnostic methods.
- These clots are currently diagnosed individually by Dr. Pretorious one by one using a fluorescent microscope, and each sample takes ~5 minutes.