The Sars Cov 2 molecule “mimics” the shape+structure of several kinds of human tissue. Thus, when antibodies are generated, they may mistake human tissue for the virus, leading to an antibody attack on one’s own body.
- Several articles have remarked on the phenomena of molecular mimicry between SARS-CoV-2 and human proteins, and have postulated a connection between this mimicry and multi-organ disorders beyond the respiratory tract (5, 9, 10, 21–23). The reasoning is that immune response against the viral antigens following infection or vaccination can cross-react with human tissue antigens that share sequence homology with the virus, resulting in autoimmune reactivity, possibly followed by outright autoimmune disease (5, 10, 19, 24, 25).
- Due to the similarity between mitochondrial dysfunction and the induction of multi-organ disorder by SARS-CoC-2, we measured the reactivity of four different antibodies made against SARS-CoV-2 proteins with M2, which is part of the pyruvate dehydrogenase complex.
- Several SARS-CoV-2 antibody cross-reactions were identified with central nervous system target proteins that included NFP, MBP, GAD-65, beta-amyloid, alpha-synuclein, synapsin and tTG-6. Compared to the other tissue antigens, NFP had the strongest reaction (very strong) with spike protein, and a very strong reaction with membrane protein that was second only to the reaction of membrane protein with M2 antigens